PTH (HUMAN, 1-34)
Teriparatide
CAS: 52232-67-4
Molecular Formula: C172H278N52O47S2
PTH (HUMAN, 1-34) - Names and Identifiers
| Name | Teriparatide |
| Synonyms | Teriparatide TERIPARATIDE PTH (HUMAN, 1-34) PTH (1-34) (HUMAN) Teriparatide acetate PARATHYROID HORMONE (HUMAN, 1-34) PARATHYROID HORMONE (1-34), HUMAN SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF |
| CAS | 52232-67-4 |
| EINECS | 640-978-1 |
| InChI | InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199) |
PTH (HUMAN, 1-34) - Physico-chemical Properties
| Molecular Formula | C172H278N52O47S2 |
| Molar Mass | 3890.49792 |
| Melting Point | >205oC (dec.) |
| Solubility | DMSO (Slightly), Water (Slightly) |
| Appearance | powder |
| Color | White to Off-White |
| Storage Condition | −20°C |
| In vivo study | Trabecular bone calcium and dry weight of the distal femur increased significantly in Teriparatide-treated animals. The increase in trabecular calcium compared with vehicle control occurred as early as 1 week after initiation of treatment with a 35% and 45% increase, respectively, for 10 μg/kg and 40 μg/kg Teriparatide. Similar results were observed for trabecular dry weight. After 4 weeks of treatment with 10 mg/kg or 40 mg/kg Teriparatide, trabecular calcium increased significantly by 70% and 123%, respectively, compared with the vehicle and by 73%. The 4-week Teriparatide administration increase the pore ratio, number, and density as well as the cortical area, thickness, and bone mineral content (BMC), without significant influencing the volumetric bone mineral density (BMD). The 4-week Teriparatide administration + 8-week vehicle administration decrease the pore ratio, number, and density as well as the cortical area and thickness, compared with the 4-week Teriparatide administration, but the pore ratio, cortical area, and thickness are still higher compared with the 12-week vehicle administration. The 4-week Teriparatide administration + 8-week higherdose IBN administration increase the cortical area, thickness, BMC, and volumetric BMD and decrease the pore ratio, but not the pore number or density, compared with the 4-week Teriparatide administration + 8-week vehicle administration. |
PTH (HUMAN, 1-34) - Risk and Safety
| WGK Germany | 3 |
| RTECS | SQ7770000 |
| HS Code | 2937190000 |
PTH (HUMAN, 1-34) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.243 ml | 1.214 ml | 2.429 ml |
| 5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
| 10 mM | 0.024 ml | 0.121 ml | 0.243 ml |
| 5 mM | 0.005 ml | 0.024 ml | 0.049 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Teriparatide Visit Supplier Webpage Request for quotationCAS: 52232-67-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Teriparatide acetate Request for quotationCAS: 52232-67-4
Tel:
Email: Anna@weierchemical.com
WhatsApp: +8618532131551
Spot supply
Product Name: Parathyroid Hormone Fragment (1-34) Visit Supplier Webpage Request for quotationCAS: 52232-67-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Product Name: Teriparatide acetate Request for quotation
CAS: 52232-67-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
WhatsApp: +8613651600618
CAS: 52232-67-4
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: 13651600618
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